This is dedicated to Jacquie, my loving
ex-mother in law who was a surrogate mum to me
for a good decade.
If I had known these things 5 years or so ago
she might be still with us now but when I press
send on this button here I know she’ll be behind
me with the biggest cheesiest grin and she’ll be
happy.
I’ve been giving dietary advice to various
friends who have been passing this information
on to relatives with differing forms of cancer.
So far all the ones who have taken this advice
are alive and also free of cancer, this is over
a period of 3 years, 2 had surgery first and no
more, one had surgery and chemo, one had chemo
and radiation.
Writing this is an attempt to get a my
interpretation of the cancer phenomena out of my
head, to describe with proof what I think the
data means and to come up with simple,
affordable and doable self treatments that can
be used with whatever other therapy is chosen.
I’d like to see the work of oncologists who
treat cancer get easier.
I also want to see people get better and get on
with their lives.
All I tell them to do is take up to 2 grams of
Bromelain with meals.
To get some form of Selenium food either from
3-4 Brazil nuts a day or from Broccoli and
Garlic.
I now recommend a bottle of Cod Liver Oil a week
(I do this for psoriasis, it’s not recommended
if pregnant).
I suggest Green Tea as Green Tea and Cod Liver
Oil work synergistically.
Some Lysine tablets, at least 3 grams worth with
cancer.
Vitamin C, preferably from food such as lemons
though Sodium Ascorbate powder will do.
I haven’t advised people to take B3 or
Nicotinamide but I now think I should.
So this is why…
I see a tumour as acting like a foetus, this is
not new as many researchers both mainstream and
alternative descibe cancer in exactly the same
way….
The
Trophoblast Theory of Cancer is now over a
hundred years old, this theory describes Cancer
cells as behaving like the invasive Trophobast
cells that occur during pregnancy.
Trophoblasts surround the new dividing
baby cells and release enzymes that create new
arteries and divert blood supplies from the main
spinal artery to the placenta.
By late pregnancy the baby is feeding off 40% of
the mother’s blood supply and a pregnancy will
fail if the trophoblast cells fail to create
those new arteries, amazing little things.
Or described in other words….
“In the case of cancer, the genetic damage
induces the stem cell to become a variant of a
trophoblast cell. Layers of trophoblast cells
are used exclusively in pregnancy to surround a
fertilized egg. Their short-lived role in
pregnancy is to attach to the uterine wall using
tiny protein pieces as hooks or tentacles and
provide a path of nutrition to the developing
embryo from the mother's normal cells. Cancer is
simply trophoblast-like cells growing in
inappropriate locations.”
The Pregnancy Connection to Cancer
Harvey Kilman has a complex read on trophoblasts
while the pictures are worth a look to get the
gist.
From Trophoblast to Human Placenta
Ralph Moss wrote about it, he’s a former
oncologist who gets pretty savage about
conventional therapy, very informative, if you
read him you’ll be tempted to take a holiday
first before any course of chemo.
THE LINK BETWEEN TROPHOBLASTS AND CANCER
CORROBORATED
Caspases are enzymes that tells
Trophoblast cells that they’re job is over and
Caspases also tell Tumor cells to shut down and
die, the word for this is
apoptosis.
These are various non-toxic dietary foods that
bring about apoptosis or tumor cell death via
caspase.
Caspases as Key Executors of Methyl
Selenium-induced Apoptosis (Anoikis) of DU-145
Prostate Cancer Cells
Selenium activates p53 and p38 pathways and
induces caspase-independent cell death in
cervical cancer cells
How can this be done?
By eating Selenium Rich foods such as Brazil
Nuts, Broccoli and Garlic.
BMP-4 and retinoic acid synergistically induce
activation of caspase-9 and cause apoptosis of
P19 embryonal carcinoma cells cultured as a
monolayer
Role of mitochondria and caspases in vitamin D
mediated apoptosis of MCF-7 breast cancer cells
How can this be done?
Cod Liver oil as recommended for Retinoic
acid/Vitamin A and Cod Liver Oil or Sunlight for
the Vitamin D.
Or lots of carrots or yellow, orange and red
vegetables if vegetarian for Vitamin A
Epigallocatechin-3-gallate Induces
Caspase-3-dependent Apoptosis in Human Gastric
Cancer Cell Line
How can this be done?
Drink Green Tea.
“The apple procyanidins increased mitochondrial
membrane permeability and cytochrome c release
from mitochondria and activated caspase-3 and
caspase-9 within the tumor cells.”
[I]
Apple
procyanidins induce tumor cell apoptosis through
mitochondrial pathway activation of caspase-3
Bear in mind here that Apricot Kernels are
illegal in the US and some countries.
People have gone to jail for selling them as but
here we have the definitive proof that Laetrile
or B17 always worked and whoever was in charge
of the FDA at that time could have stopped
millions of people from dying, what were they
thinking?
It’s even better than that, caspase-3 and
caspase-9 are kind of the aces of spades of
tumor cascades in my book
“Our data show that curcumin activates
caspases-3 and -8 but not caspase-9, supporting
the rationale that apoptosis occurs via a
membrane-mediated mechanism.”
Curcumin Induces Apoptosis in Human Melanoma
Cells through a Fas Receptor/Caspase-8 Pathway
Independent of p53
How can this be done?
Turmeric in curries will do the trick
“Results demonstrated that the activation of
caspase-3, caspase-8, and caspase-9 is an
important determinant of apoptotic death induced
by aloe-emodin.”
Effects and mechanisms of aloe-emodin on cell
death in human lung squamous cell carcinoma
How can this be done?
Drink Aloe Vera, ugh.
The body needs enzymes to create Caspase
otherwise the things above won’t work and I
believe
Bromelain is the safest and
proven enzyme to effect tumours.
The other brilliant thing about Bromelain is
that it mimics Pancreatic enzymes and this helps
digestion and in particular digestion of the
sugars which tumour cells can live off.
Bromelain also knocks off CD44 receptors from
tumour cells, this prevents them from attaching
to other cells and of course stops the spread of
cancer.
“Bromelain is a pharmacologically active
compound, present in stems and immature fruits
of pineapples (Ananas cosmosus), which has been
shown to have anti-edematous, anti-inflammatory,
anti-thrombotic and anti-metastatic properties.”
“Results showed that bromelain application
delayed the onset of tumorigenesis and reduced
the cumulative number of tumors, tumor volume
and the average number of tumors/mouse. To
establish a cause and effect relationship, we
targeted the proteins involved in the cell death
pathway. Bromelain treatment resulted in
upregulation of p53 and Bax and subsequent
activation of caspase 3 and caspase 9 with
concomitant decrease in antiapoptotic protein
Bcl-2 in mouse skin.”
Regulation of p53, nuclear factor kappaB and
cyclooxygenase-2 expression by bromelain through
targeting mitogen-activated protein kinase
pathway in mouse skin.
You will find with a simple Google that many
chemotherapy drugs affect caspases and this is
one of the main reasons that they work, the only
problem is that chemotherapy is invariably toxic
to other cells, that’s why I use simple foods
that do the same thing.
These are examples of chemotherapy drugs that
induces caspase activity.
Actinomycin D ,
Acrolein,
Doxorubicin,
Bleomycin ,
Carboplatin,
Cladribine,
CannabinoidsEtoposide,
Ginseng,
Alemtuzumab,
Flavopirido,
Fludarabine,
Retinoids,
13-cis-retinoic acid ,
Tamoxifen,
Taxol,
Caspase-8 in apoptosis of hepatoma cell induced
by 5-fluorouracil.
This is the prognosis for you using 5-fluorocil.
“Pancreatic cancer remains a major unsolved
health problem, with conventional cancer
treatments having little impact on disease
course. Almost all patients who have pancreatic
cancer develop metastases and die. The main risk
factors are smoking, age, and some genetic
disorders, although the primary causes are
poorly understood. Advances in molecular biology
have, however, greatly improved understanding of
the pathogenesis of pancreatic cancer. Many
patients have mutations of the K-ras oncogene,
and various tumour-suppressor genes are also
inactivated. Growth factors also play an
important part. However, disease prognosis is
extremely poor. Around 15-20% of patients have
resectable disease, but only around 20% of these
survive to 5 years. For locally advanced,
unresectable, and metastatic disease, treatment
is palliative, although fluorouracil
chemoradiation for locally advanced and
gemcitabine chemotherapy for metastatic disease
can provide palliative benefits.”
Pancreatic cancer.
And Bromelain works better than 5-FU anyway…
“The antitumoral activity was assessed by the
survival increase (% survival index) following
various treatments. With the exception of MB-F10
melanoma, all other tumor-bearing animals had a
significantly increased survival index after
bromelain treatment. The largest increase (
approximately 318 %) was attained in mice
bearing EAT ascites and receiving 12.5 mg/kg of
bromelain. This antitumoral effect was superior
to that of 5-FU, whose survival index was
approximately 263 %, relative to the untreated
control. Bromelain significantly reduced the
number of lung metastasis induced by LLC
transplantation, as observed with 5-FU.”
In Vivo Antitumoral Activity of Stem Pineapple (Ananas
comosus) Bromelain.
You can probably work out your dose with that
formula?
“12.5 mg/kg of bromelain.”
Multiply 0.0125 by your weight.
Mine is only 800g, I take 2000g because it makes
my skin well.
Love it.
I think the Queensland
Pineapple growers need some marketing.
I’ll quickly mention Wormwood, it’s kind of
gross to drink but I like it, this is the result
of an extract but Wormwood tea works anyway,
neat results.
“Results. In this study, the deoxoartemisinin
trimer had the most potent antitumor effect
(IC50 = 6.0 M), even better than paclitaxel
(IC50 = 13.1 M), on oral cancer cell line
(YD-10B). In addition, it induced apoptosis
through a caspase-3-dependent mechanism.”
Conclusion. The deoxoartemisinin trimer was
found to have greater antitumor effect on tumor
cells than other commonly used chemotherapeutic
drugs, such as 5-FU, cisplatin, and paclitaxel.
Effects of artemisinin and its derivatives on
growth inhibition and apoptosis of oral cancer
cells
Just little things like that are useful and as
you add a whole arrangement of every day foods
as well as teas to your conventional treatment
your chances simply increase.
I must warn people to avoid sugar so your
pancreas doesn’t have to work harder.
There were about 20 clinics successfully using
pancreatic enzymes for cancer at the
beginning of the last century and they simply
went out of fashion, don’t you love fashion.
Your pancreas breaks down sugars and so needs
enzymes to do that.
"These results are far above the survival at one
year and survival at two years for all stages of
pancreatic adenocarcinoma reported in the
National Cancer Data Base from 1995. This pilot
study suggests that an aggressive nutritional
therapy with large doses of pancreatic enzymes
led to significantly increased survival over
what would normally be expected for patients
with inoperable pancreatic adenocarcinoma."
Evaluation of pancreatic proteolytic enzyme
treatment of adenocarcinoma of the pancreas,
with nutrition and detoxification support.
If you add these foods to your diet it simply
adds enzymes to digest sugars and the rest.
Bromelain is the lazy way to do it, I use it and
it stops any psoriasis nicely.
I’m too lazy to eat fruit.
(:
"The best food sources of digestive enzymes are:
sprouts (easy and inexpensive to grow on your
own), unripe papaya, unripe pineapple, avocados,
bananas, and mangos."
Enzymes
Selenium and cancer
I put Brazil nuts in muesli (about 3 to 4, not
every night) and you can throw Broccoli and
Garlic into all sorts of meals.
Seafood also has heaps of Selenium.
They are all foods you can get selenium from.
Selenium foods like that also add the building
blocks for the cell protective anti-oxidant
Glutathione.
And also for Methylation, more on that at the
end.
Brazil nuts can stop night sweats if needed,
works every time I tell friends.
Night sweats and weight loss are hyperthyroid
symptoms and generally the first signs of
selenium or
copper deficiency.
And it’s useful to know that copper foods like
cashews can be used to put weight on if patients
get caxechia.
"This paper reports the results of two mammary
cancer prevention experiments in the rat
dimethylbenz[a]anthracene model by continuous
feeding of selenium-rich Brazil nut (processed
to a smooth-textured nut material for mixing in
the diet). A dose-dependent inhibitory response
was observed at dietary selenium concentrations
of 1-3 micrograms/g. Interestingly, Brazil nut
was found to be just as powerful as sodium
selenite, if not more so, at similar levels of
dietary selenium intake."
Bioactivity of selenium from Brazil nut for
cancer prevention and selenoenzyme maintenance.
"These results demonstrate that dietary
supplementation of selenomethionine reduced
experimental metastasis of melanoma cells in
mice and inhibited the growth of metastatic
tumors that formed in the lungs."
Dietary supplementation of selenomethionine
reduces metastasis of melanoma cells in mice
See it works….
The reason for this advice is here and it may
sound confusing but I should show it.
Brazil nuts have Selenomethionine and that is a
building block to make S-Adenosylmethionine or
SAM.
"SAM is derived from an ATP-dependent transfer
of adenosine to methionine via methionine
adenosyltransferase and serves as the proximal
methyl donor for most methylation reactions."
"The formation of SAM requires a continuous
supply of folate, methionine, choline, vitamin
B12, vitamin B6, vitamin B2 and energy from the
extracellular milieu.
"Higher DNA methyltransferase activity has been
observed in tumor cells compared to normal
cells. Chronic dietary methyl deficiency also
increases DNA methyltransferase activity, which
may be an attempt to compensate for diminished
SAM supply. Nutrient supply, therefore, appears
to play a key role in regulating DNA
methyltransferase activity."
DIET, DNA METHYLATION AND OTHER EPIGENETIC
EVENTS, AND CANCER PREVENTION
What’s it all mean?
Well if “Higher DNA methyltransferase activity
has been observed in tumor cells compared to
normal cells.”
Then Higher DNA methyltransferase is not good.
If these nutrients “folate, methionine, choline,
vitamin B12, vitamin B6, vitamin B2” are low
then there’s not enough SAM to stop the “Higher
DNA methyltransferase activity”
I don’t agree with Folic acid inhibitors as a
result, I don’t think you should take a
supplement of Folic acid either, just get it by
eating well.
Here is the Methionine content of Brazils.
"The proteins found in Brazil nuts are very high
in sulfur-containing amino acids like cysteine
(8%) and methionine (18%) and are also extremely
rich in glutamine, glutamic acid, and arginine."
A hard nut cracked: Brazil nuts' selenium
compounds identified
Garlic may be a bit safer, in this study less
Selenium accumulated in the bones than Brazil
nuts but since this is cancer I suggested Brazil
nuts because you get more easily with less
Garlic breath.
Use Broccoli too, it's another good source.
"This suggests that the anti-cancer activity of
the high-selenium garlic was likely to be
accounted for by the effect of selenium, rather
than the effect of garlic per se."
"Thus, based on the results of several
biological responses, it appears that the
ability of the high-selenium garlic to protect
against tumorigenesis is primarily dependent on
increased intake of selenium provided by the
vegetable."
Efficacy of cancer prevention by high-selenium
garlic is primarily dependent on the action of
selenium.
The same goes for Choline, nuts and eggs have it
and your liver should make Choline in your body.
Beetroot has some of the best Choline in the
form of Betaine so maybe drop into a juice bar
for a Beetroot and Carrot mix or your wonderful
choice of what would go with Beetroot?
Yummy.
I don’t recommend eggs at all because they have
high levels of
Sialic acid and so do the cell surfaces of
cancer cells, something to consider.
Whey powder also has very high levels
Sialic acid, I know it gets used as a food
for cancer patients, I would avoid whey and eggs
myself.
‘Sialomucins are abundant on the surfaces of
certain ascites tumor cells and have been
implicated in the escape of tumors from immune
destruction and metastasis.
Structural and functional aspects of tumor cell
sialomucins
I also look at it another way.
Sialic acid is great for growing babies, it’s
good for their nerve development, it’s also good
for Alzheimer’s possibly for a similar reason.
What good for growing babies though also feeds a
tumor because it acts like
fetus.
So eggs, whey powder and milk are all baby
foods.
Avoiding them helps.
Methionine is needed to make Carnitine….so I’ll
show you Carnitine.
"In cancer patients, abnormalities of tumor
tissue as well as nontumor tissue metabolism
have been observed. Such abnormalities are
supposed to contribute to deterioration of
clinical status of patients, or might induce
cancerogenesis by themselves. The carnitine
system appears abnormally expressed both in
tumor tissue, in such a way as to greatly reduce
fatty acid beta-oxidation, and in nontumor
tissue. In this view, the study of the carnitine
system represents a tool to understand the
molecular basis underlying the metabolism in
normal and cancer cells. Some important
anticancer drugs contribute to dysfunction of
the carnitine system in nontumor tissues, which
is reversed by carnitine treatment, without
affecting anticancer therapeutic efficacy."
Cancer and anticancer therapy-induced
modifications on metabolism mediated by
carnitine system.
So this is how your body makes Carnitine.
"It can be synthesised within the body from the
amino acids lysine or methionine. Vitamin C
(Ascorbic acid) is essential to the synthesis of
carnitine."
Carnitine
It is one reason why I mention
Lysine.
Lysine has many uses, because it’s the main
building block of collagen it should be used in
the clinical health setting for any degenerative
disease, heart disease, cancers and all
autoimmune diseases.
Lysine stops all Herpes diseases and it’s the
only thing that always works.
So if a patients gets an outbreak of Chickenpox
or Cold Sores while on Chemotherapy the first
thing to do is take Lysine, serious cases can be
treated with any high dose, it’s so non toxic.
Success of L-lysine therapy in frequently
recurrent herpes simplex infection. Treatment
and prophylaxis.
Foods to avoid are Corn, Eggs, Chocolate and
Peanuts because the high Arginine content in
these foods feeds Herpes viruses.
The reason why avoiding Herpes attacks is so
important is because every attack depletes
Lysine and makes your Collagen or skin and
arteries weaker.
Cancer cells and fetal trophoblast cells release
Collagen destroying enzymes.
Weaker Collagen allows a tumor to spread.
So this study shows some effects on breast
cancers induced in rats and then treated with
the mix of Lysine, Proline, Arginine, Vitamin C
(ascorbic acid) and
Green tea.
You really should get enough Arginine if you
just eat well.
"The limited ability of current treatments to
control metastasis and the proposed antitumor
properties of specific nutrients prompted us to
examine the effect of a specific formulation
(nutrient supplement [NS]) of lysine, proline,
arginine, ascorbic acid, and green tea extract
in vivo on the development of N-methyl-N-nitrosourea
(MNU)-induced mammary tumors in rats."
"Results: NS reduced the incidence of MNU-induced
mammary tumors and the number of tumors by
68.4%, and the tumor burden by 60.5%. The
inhibitory effect of NS was also reflected by
decreased tumor weight; the tumor weights per
rat and per group were decreased by 41% and 78%,
respectively. In addition, 30% of the control
rats developed ulcerated tumors, in contrast to
10% in the nutrient supplemented rats.
Conclusion: These findings suggest that the
specific formulation of lysine, proline,
arginine, ascorbic acid, and green tea extract
tested significantly reduces the incidence and
growth of MNU-induced mammary tumors, and
therefore has strong potential as a useful
therapeutic regimen for inhibiting breast cancer
development."
Modulation of N-methyl-N-nitrosourea induced
mammary tumors in Sprague–Dawley rats by
combination of lysine, proline, arginine,
ascorbic acid and green tea extract 2005
Or poor mice….
“Results demonstrate that the nutrient mixture
of lysine, proline, arginine, ascorbic acid, and
green tea extract tested strongly suppressed the
growth of tumors without adverse effects in nude
mice, suggesting potential as an anticancer
agent.
Effect of ascorbic acid, lysine, proline and
green tea extract on human osteosarcoma cell
line MNNG-HOS xenografts in nude mice
The Lysine, Proline, Arginine and Ascorbic Acid
are needed for Collagen repair and since Cancer
releases enzymes that destroy Collagen by
recreating your Collagen with the right foods
you then neutralize those enzymes.
Lysine tablets and Sodium Ascorbate powder can
be bought from chemists and health stores.
Don't take too much Ascorbate or you end up
moving the bowels too quickly.
Lemons are the best for the Vitamin C, two
halves squeezed in water or juice a day is easy,
more is better.
The best foods with Lysine are fish or Mung bean
sprouts.
I don’t trust Soy as a Lysine source, my
opinion.
Green tea stops angiogenesis.
Angiogenesis is how our body makes new arteries,
cancer cells also divert blood supply and
arteries to feed themselves and Green Tea helps
stop that.
Epigallocatechin-3-gallate is the stuff that
comes out of Green Tea so here's a study.
"We report that compared to non-EGCG-treated
tumors, topical application of EGCG in
UV-induced tumors resulted in inhibition of
protein expression and activity of matrix
metalloproteinase (MMP)-2 and MMP-9, which play
crucial roles in tumor growth and metastasis. In
contrast, tissue inhibitor of MMP-1 (TIMP-1),
which inhibits MMP activity, was increased in
tumors."
Epigallocatechin-3-gallate inhibits
photocarcinogenesis through inhibition of
angiogenic factors and activation of CD8[+] T
cells in tumors
Here they talk about cancer destroying collagen,
proteinases are the collagen destroying enzymes
that these foods will stop.
"Breast cancer cells frequently metastasize to
the skeleton and induce extensive bone
destruction. Cancer cells produce proteinases,
including matrix metalloproteinases (MMPs) and
the plasminogen activator system (PAS) which
promote invasion of extracellular matrices, but
whether these proteinases degrade bone matrix is
unclear."
"ResultsThe 3 breast cancer cell lines all
produced significant degradation of the 3
collagenous extracellular matrices (ECMs) whilst
the normal breast cell line was without effect."
Human breast cancer cell-mediated bone collagen
degradation requires plasminogen activation and
matrix metalloproteinase activity
So here's a description of Collagen.
"Collagen is the main protein of connective
tissue in animals and the most abundant protein
in mammals, making up about 25% of the total
protein content.'
"Prolines and lysines at specific locations
relative to glycine are modified post-translationally
by different enzymes, both of which require
Vitamin C as a cofactor."
"Vitamin C deficiency causes scurvy, a serious
and painful disease in which defective collagen
prevents the formation of strong connective
tissue. Gums deteriorate and bleed, with loss of
teeth; skin discolors, and wounds do not heal."
Collagen
This is why Vitamin C is needed for sick people,
without it we actually fall apart.
Green tea also has this awesome quality of being
able to block Laminin receptors.
Ok you’re going what?
Laminin is like a foundation layer of collagen.
Tumor cells love jumping onto
Laminin just as a trophoblast fetal cell
does.
If you throw in enough Green tea it blocks it
and the tumor can’t jump on and spread.
If you make enough collagen it’s like putting a
wall around a tumor and stopping it too.
"Laminin was significantly higher in breast
cancer patients than in normal controls. Serum
laminin levels were also significantly higher in
patients with metastasis than in those without
metastasis."
Evaluation of serum laminin as a tumor marker in
breast cancer
"One protein component of the matrix of
molecules that both surrounds a cell and forms
the basement membrane is called laminin. Breast
cancer cells attach to laminin using a specific
laminin-binding protein (LBP), a cell surface
protein."
Novel drugs to inhibit breast cancer metastasis
"The growth of solid tumors is largely
controlled by the process of angiogenesis. A 67
kDa protein, the laminin binding protein (LBP),
is shed from malignant cells in significant
amounts and binds to laminin-1"
Tumor shedding of laminin binding protein
modulates angiostatin production in vitro and
interferes with plasmin-derived inhibition of
angiogenesis in aortic ring cultures
Green tea works even better if Retinoic Acid is
around.
15 Mar 2004
“The investigators explain that the laminin
receptor is expressed on several types of tumor
cells, and its expression level "strongly
correlates with the risk of tumor invasion and
metastasis."
Previous research has identified green tea's
major polyphenol, (-)-epigallocatechin-3-gallate
(EGCG), as it active antitumorigenic component
(see Reuters Health report, October 17 2003).
Dr. Hirofumi Tachibana and colleagues at Kyushu
University in Fukuoka found that
all-trans-retinoic acid enhances EGCG binding to
the 67-LR on the surface of cancer cells.
According to their report in Nature Structural
and Molecular Biology, published online March
14, EGCG at a plasma concentration equivalent to
that achieved after drinking two or three cups
of green tea inhibited growth of lung cancer
cells transfected with the 67-LR gene. Adding
laminin or an antibody to 67-LR to the mix
reduced EGCG's binding affinity.”
Laminin receptor mediates anticancer effects of
green tea
So I myself use Cod Liver Oil for the
Vitamin
A or Retinoic acid for the skin.
Retinoic Acid get used for all sorts of
Cancers including Leukemia.
I could show many, many studies that work.
The other sources are just the red and yellow
vegetables, so Carrot juice, Pumpkins, Tomatoes
are all useful.
"Retinoids, the natural and synthetic vitamin A
derivatives, are effective in inhibiting the
proliferation of breast cancer cells."
Prevention of Breast Cancer Tumor Growth by
Retinoic Acid
The other sources are just the Beta-Carotene’s
in red and yellow vegetables, so Carrot juice,
Pumpkins, Tomatoes are all useful foods in
cancer therapy.
“In this study, we examined possible mechanisms
of caspase activation during carotenoid-induced
apoptosis in tumor cells. We found that
beta-Carotene induces apoptosis by the
activation of caspase-3 in human leukemia
(HL-60), colon adenocarcinoma (HT-29) as well as
melanoma (SK-MEL-2) cell lines. This activation
is dose dependent and follows that of caspase-8
and caspase-9.”
“These results support a pharmacological role
for beta-Carotene as a candidate antitumor agent
and show a possible sequence of molecular events
by which this molecule may induce apoptosis in
tumor cells.”
Mechanism of activation of caspase cascade
during beta-carotene-induced apoptosis in human
tumor cells.
Now I mentioned Methylation before, this is a
research idea of mine to measure the nutrients
that are needed for Methylating our DNA and
keeping retroviruses within our DNA and not
jumping around too much.
Measuring Methylation and Retroviruses and my
rant afterwards, scary me.
A weird thing happens with both fetuses and
cancers, there’s heaps of our own retroviruses
around.
So what happens as
trophoblast cells burrow into the mum to
make new arteries, retroviruses like
HERV-W
do the fusing together or some part of the
dismantling and rebuilding that’s going on.
Without these retroviruses the baby may not get
a proper artery for food.
These retroviruses also seem vital for attaching
the baby to the placental wall and keeping it
there.
All new biology.
You can find HERV-W in some tumors too.
L1 and HERV-W retrotransposons are
hypomethylated in human ovarian carcinomas
DNA methylation and expression of LINE-1 and
HERV-K provirus sequences in urothelial and
renal cell carcinomas
Syncytin is a captive retroviral envelope
protein involved in human placental
morphogenesis.
Trophoblast fusion: fusogenic proteins,
syncytins and ADAMs, and other prerequisites for
syncytial fusion.
One of the things that signals to these critters
to come out is
Vitamin A or Retinoic Acid, Vitamin D is one of
the other ones.
That’s why I’m a fan of Cod Liver Oil.
I’m also sure that if enough Selenium nutrients
are in the diet this cancels out any toxic
effects of Retinoic Acid at higher doses.
This is because
Retinoic acid makes the DNA
demethylate
, while Selenium remethyaltes.
All about balance, I could ramble better not…..
I’ll just mention pain…no I’ll just show you a
study of cancer patients injecting Epsom Salts
and you can decide.
We should us it.
“Neuropathic pain may respond poorly to morphine
and is often difficult to relieve. Recent
attention has been drawn to the role of the
N-methyl-D-aspartate (NMDA) receptor in the
potentiation of neuropathic pain. Magnesium is
known to block the NMDA receptor. It reduces the
neuropathic pain response in animals, and
attenuates postoperative pain and migraine in
humans. We have examined the safety,
tolerability, and efficacy of two intravenous
doses of magnesium sulfate in 12 patients with
neuropathic pain due to malignant infiltration
of the brachial or lumbosacral plexus. The first
six patients received 500 mg, the remainder 1 g.
Apart from a mild feeling of warmth at the time
of the injection, both doses were well
tolerated. After receiving 500 mg, three
patients experienced complete pain relief and
two experienced partial pain relief for up to 4
hours duration; pain was unchanged in one
patient. After receiving 1 g, one patient
experienced complete relief and four experienced
partial pain relief of similar duration; pain
was unchanged in one patient. Intravenous
magnesium sulfate in these doses appears to be
safe and well tolerated. A useful analgesic
effect may be obtained in some patients and
further evaluation is warranted.”
The safety and efficacy of a single dose (500 mg
or 1 g) of intravenous magnesium sulfate in
neuropathic pain poorly responsive to strong
opioid analgesics in patients with cancer.
And
Niacin, Vitamin B3 or Nicotinamide, I
take a gram most days, it fixes wounds and
dandruff in my experience, you can decide, this
is all for you to decide.
“Current research suggests niacin, or vitamin
B3, may play a key role in cancer prevention
through its activities in cellular repair.
Leading scientists involved in niacin nutrition
believe the vitamin shows promise in treating
and even preventing cancer.
Myron K. Jacobson, Ph.D., and Elaine Jacobson,
Ph.D., researchers at the Texas College of
Osteopathic Medicine, Fort Worth, have
demonstrated that cells depleted of niacin
develop cancer ten times faster than those
having sufficient amounts of the vitamin. Diet
is a major risk factor, with both beneficial and
detrimental components, and niacin is one of the
beneficial components, according to the
Jacobson.”
Niacin shows positive results in cancer research
“The dietary status of niacin (vitamin B3) has
the potential to influence DNA repair, genomic
stability, and the immune system, eventually
having an impact on cancer risk, as well as the
side effects of chemotherapy in the cancer
patient.’
“There are various sources of evidence that
niacin status does have an impact on cancer
risk, including animal models of leukemogenesis
and skin cancer, as well as epidemiological data
from human populations.”
Niacin and Carcinogenesis
Well I think my hero in all of this is
Nicholas Culpeper (1616-1654) his books on
herbs probably opened the pharmaceutical
cupboard because his philosophy was that all of
this knowledge was of no use to anyone if only a
few doctors knew about it.
Just by raising the learning curve for everyone
and including the sick in the decision making
and discussion of what works when near death
then becomes practical medicine.
I use all of these things, I can say I WAS
rather ill and now I’m not, it was to fix my
skin and not for cancer but I learnt a lot on
the way.
I’ll mention Echinacea just for old Culpeper, it
has cascades too, he’d be happy to know.
But this is the one that’ll make him chuckle.
"Echinacea pallida extract was able to induce
apoptosis by increasing significantly caspase
3/7 activity and promoting nuclear DNA
fragmentation."
Cytotoxic effects of Echinacea root hexanic
extracts on human cancer cell lines
“Three months after leukemia onset—long after
all control (untreated chow) leukemic mice had
died…”
“Echinacea-consuming, originally leukemic mice
were indistinguishable from the corresponding
populations of cells in normal mice.”
“One-third of all Echinacea-consuming mice that
survived until 3 months after leukemia onset
went on to live a full-life.”
Echinacea: a Miracle Herb against Aging and
Cancer? Evidence In vivo in Mice
I want to thank all the
rats
and mice who made this possible because I’m
pinching their death data a fair bit, I’d like
to say sorry guys.
And
Andrew
Maniotis for feedback, he can
disagree.
(:
Plus
Beth Newman likewise, I found Caspases by
accident from a conversation.
I’d like say hi to Mum and Dad in Blighty, my
dad in particular for his attitude to how you
deal with cancer.
He has a Patent on a salt bag to treat external
cancers.
He knows it works because he’s used it, one lump
is left on his head but it’s not growing and he
soaks it with salt these days.
And salt works…we should use it.
"OBJECTIVE. The objective of our study was to
evaluate the efficacy of hypertonic saline for
the treatment of liver tumors.
MATERIALS AND METHODS. Thirty New Zealand white
rabbits inoculated with VX2
carcinoma in the liver were included in this
experiment. These animals were divided into two
groups: one for the evaluation of survival time
(n = 20) and the other, for tumor size (n = 10).
Each group was divided further into control and
treatment subgroups. Hypertonic saline was
injected directly into the liver tumor of the
treatment group under CT guidance 10 days after
inoculation.
The liver tumor in the control group was
injected with normal saline.
The group for evaluation of tumor size was
sacrificed 14 days later. The other group was
raised until they died.
RESULTS. The survival time of the rabbits in the
treatment group (38.1 ± 2.3 days) was
significantly longer (p < 0.001) than that of
the untreated group (29.9 ± 2.9 days). For tumor
size, the difference between the treatment group
(8.04 ± 2.46 cm2) and the control group (11.08 ±
2.52cm2) was also significant (p < 0.05).
CONCLUSION. Hypertonic saline injection had the
effect of controlling the growth of
VX2 carcinoma cells and extending the life of
rabbits.
It deserves further investigation.
If my dad visits a doctor he’ll put a cap over
the lump.
My favourite quotes from him….in a thick
Northern Irish accent.
“It’s cos all the relatives freak out and scare
them to death”
He might be right there so stay calm as possible
everybody.
And “It’s not the cancer that kills you it’s the
treatment”
Well I just wrote this so we could all get on
the right road.